Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing—Using Rifampicin as an Example

Rifampicin exhibits complexities in its pharmacokinetics (PK), including high inter-occasion variability (IOV), which is challenging for dose individualization. Model-informed precision dosing (MIPD) can be used to optimize individual doses. In this simulation-based study we investigated the magnitu...

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Bibliografische gegevens
Gepubliceerd in:Front Pharmacol
Hoofdauteurs: Keutzer, Lina, Simonsson, Ulrika S. H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020
Onderwerpen:
Pharmacology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266983/
https://ncbi.nlm.nih.gov/pubmed/32536870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00794
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