Chitosan-capped enzyme-responsive hollow mesoporous silica nanoplatforms for colon-specific drug delivery

An enzyme-responsive colon-specific delivery system was developed based on hollow mesoporous silica spheres (HMSS) to which biodegradable chitosan (CS) was attached via cleavable azo bonds (HMSS–N=N–CS). Doxorubicin (DOX) was encapsulated in a noncrystalline state in the hollow cavity and mesopores...

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Detalhes bibliográficos
Publicado no:Nanoscale Res Lett
Main Authors: Cai, Defu, Han, Cuiyan, Liu, Chang, Ma, Xiaoxing, Qian, Jiayi, Zhou, Jianwen, Li, Yue, Sun, Yiming, Zhang, Changting, Zhu, Wenquan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2020
Assuntos:
Nano Express
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266918/
https://ncbi.nlm.nih.gov/pubmed/32488526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s11671-020-03351-8
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