Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis

Despite the introduction of biologics, topical dithranol (anthralin) has remained one of the most effective anti-psoriatic agents. Serial biopsies from human psoriatic lesions and both the c-Jun/JunB and imiquimod psoriasis mouse model allowed us to study the therapeutic mechanism of this drug. Top...

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Vydáno v:eLife
Hlavní autoři: Benezeder, Theresa, Painsi, Clemens, Patra, VijayKumar, Dey, Saptaswa, Holcmann, Martin, Lange-Asschenfeldt, Bernhard, Sibilia, Maria, Wolf, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Immunology and Inflammation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266641/
https://ncbi.nlm.nih.gov/pubmed/32484435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56991
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