An LC-MS/MS Bioanalytical Assay for the Determination of Gilteritinib in Rat Plasma and Application to a Drug–Drug Interaction Study

BACKGROUND: Gilteritinib, a novel, potent FLT3/AXL inhibitor, was recently approved in Japan and USA for the treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation. PURPOSE AND METHODS: In this study, we aimed to develop and validate a sensitive...

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Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Wang, Qiong, Chen, Zhe, Chen, Dingwen, Ye, Xia-yan
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266109/
https://ncbi.nlm.nih.gov/pubmed/32546970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S243760
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