The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer

The antiandrogen enzalutamide (Enz) has improved survival in castration resistant prostate cancer (CRPC) patients. However, most patients eventually develop Enz resistance that may involve inducing the androgen receptor (AR) splicing variant 7 (ARv7). Here we report that high expression of monoamine...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Keliang, Luo, Jie, Yeh, Shuyuan, You, Bosen, Meng, Jialin, Chang, Philip, Niu, Yuanjie, Li, Gonghui, Lu, Changxue, Zhu, Yezi, Antonarakis, Emmanuel S., Luo, Jun, Huang, Chi-Ping, Xu, Wanhai, Chang, Chawnshang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264333/
https://ncbi.nlm.nih.gov/pubmed/32483206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15396-5
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