Multifaceted mechanisms of colistin resistance revealed by genomic analysis of multidrug-resistant Klebsiella pneumoniae isolates from individual patients before and after colistin treatment

OBJECTIVES: Polymyxins (i.e. polymyxin B and colistin) are used as a last-line therapy to combat multidrug-resistant (MDR) Klebsiella pneumoniae. Worryingly, polymyxin resistance in K. pneumoniae is increasingly reported worldwide. This study identified the genetic variations responsible for high-le...

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Detalhes bibliográficos
Publicado no:J Infect
Main Authors: Zhu, Yan, Galani, Irene, Karaiskos, Ilias, Lu, Jing, Aye, Su Mon, Huang, Jiayuan, Yu, Heidi H., Velkov, Tony, Giamarellou, Eleni, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264071/
https://ncbi.nlm.nih.gov/pubmed/31374222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinf.2019.07.009
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