Clonal Evolution and Heterogeneity of Osimertinib Acquired Resistance Mechanisms in EGFR Mutant Lung Cancer

Clonal evolution of osimertinib-resistance mechanisms in EGFR mutant lung adenocarcinoma is poorly understood. Using multi-region whole-exome and RNA sequencing of prospectively collected pre- and post-osimertinib-resistant tumors, including at rapid autopsies, we identify a likely mechanism driving...

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Detalhes bibliográficos
Publicado no:Cell Rep Med
Main Authors: Roper, Nitin, Brown, Anna-Leigh, Wei, Jun S., Pack, Svetlana, Trindade, Christopher, Kim, Chul, Restifo, Olivia, Gao, Shaojian, Sindiri, Sivasish, Mehrabadi, Farid, El Meskini, Rajaa, Ohler, Zoe Weaver, Maity, Tapan K., Venugopalan, Abhilash, Cultraro, Constance M., Akoth, Elizabeth, Padiernos, Emerson, Chen, Haobin, Kesarwala, Aparna, Smart, DeeDee K., Nilubol, Naris, Rajan, Arun, Piotrowska, Zofia, Xi, Liqiang, Raffeld, Mark, Panchenko, Anna R., Sahinalp, Cenk, Hewitt, Stephen, Hoang, Chuong D., Khan, Javed, Guha, Udayan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263628/
https://ncbi.nlm.nih.gov/pubmed/32483558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100007
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