Intragenic suppressor mutations of the COQ8 protein kinase homolog restore coenzyme Q biosynthesis and function in Saccharomyces cerevisiae

Saccharomyces cerevisiae Coq8 is a member of the ancient UbiB atypical protein kinase family. Coq8, and its orthologs UbiB, ABC1, ADCK3, and ADCK4, are required for the biosynthesis of coenzyme Q in yeast, E. coli, A. thaliana, and humans. Each Coq8 ortholog retains nine highly conserved protein kin...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Awad, Agape M., Nag, Anish, Pham, Nguyen V. B., Bradley, Michelle C., Jabassini, Nour, Nathaniel, Juan, Clarke, Catherine F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263595/
https://ncbi.nlm.nih.gov/pubmed/32479562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0234192
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