Elevated ACE2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication

The site of SARS-CoV-2 entry and replication critically impacts strategies for COVID-19 diagnosis, transmission mitigation, and treatment. We determined the cellular location of the SARS-CoV-2 target receptor protein, ACE2, in the human upper airway, finding striking enrichment (200–700 folds) in th...

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Publicat a:bioRxiv
Autors principals: Chen, Mengfei, Shen, Wenjuan, Rowan, Nicholas R., Kulaga, Heather, Hillel, Alexander, Ramanathan, Murugappan, Lane, Andrew P.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263519/
https://ncbi.nlm.nih.gov/pubmed/32511390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.05.08.084996
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