Convection-enhanced delivery of botulinum toxin serotype A into the nonhuman primate cisterna magna and hippocampus

OBJECTIVE: Botulinum toxin serotype A (BoNT/A) was reported to raise the seizure threshold when injected into the seizure focus of a kindled rodent model. Delivering BoNT/A to the nonhuman primate (NHP) central nervous system via convection-enhanced delivery (CED) has not been performed. The objecti...

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Détails bibliographiques
Publié dans:J Neurosurg
Auteurs principaux: Argersinger, Davis P., Walbridge, Stuart, Wetjen, Nicholas M., Vortmeyer, Alexander O., Wu, Tianxia, Butman, John A., Heiss, John D.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263482/
https://ncbi.nlm.nih.gov/pubmed/31323637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/2019.4.JNS19744
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