Phase-plate cryo-EM structure of the Widom 601 CENP-A nucleosome core particle reveals differential flexibility of the DNA ends

The histone H3 variant CENP-A marks centromeres epigenetically and is essential for mitotic fidelity. Previous crystallographic studies of the CENP-A nucleosome core particle (NCP) reconstituted with a human α-satellite DNA derivative revealed both DNA ends to be highly flexible, a feature important...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Boopathi, Ramachandran, Danev, Radostin, Khoshouei, Maryam, Kale, Seyit, Nahata, Sunil, Ramos, Lorrie, Angelov, Dimitar, Dimitrov, Stefan, Hamiche, Ali, Petosa, Carlo, Bednar, Jan
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261176/
https://ncbi.nlm.nih.gov/pubmed/32313946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa246
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