IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway

Resistance to androgen receptor (AR) targeting therapeutics in prostate cancer (PC) is a significant clinical problem. Mechanisms by which this is accomplished include AR amplification and expression of AR splice variants, demonstrating that AR remains a key therapeutic target in advanced disease. F...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Bainbridge, Alex, Walker, Scott, Smith, Joseph, Patterson, Kathryn, Dutt, Aparna, Ng, Yi Min, Thomas, Huw D, Wilson, Laura, McCullough, Benjamin, Jones, Dominic, Maan, Arussa, Banks, Peter, McCracken, Stuart R, Gaughan, Luke, Robson, Craig N, Coffey, Kelly
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261174/
https://ncbi.nlm.nih.gov/pubmed/32324216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa271
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