Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis

In the fight against antimicrobial resistance, the bacterial DNA sliding clamp, β-clamp, is a promising drug target for inhibition of DNA replication and translesion synthesis. The β-clamp and its eukaryotic homolog, PCNA, share a C-terminal hydrophobic pocket where all the DNA polymerases bind. Her...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Nedal, Aina, Ræder, Synnøve B, Dalhus, Bjørn, Helgesen, Emily, Forstrøm, Rune J, Lindland, Kim, Sumabe, Balagra K, Martinsen, Jacob H, Kragelund, Birthe B, Skarstad, Kirsten, Bjørås, Magnar, Otterlei, Marit
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261172/
https://ncbi.nlm.nih.gov/pubmed/32347931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa278
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