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Extinction of all infectious HIV in cell culture by the CRISPR-Cas12a system with only a single crRNA
The CRISPR-Cas9 system has been used for genome editing of various organisms. We reported inhibition of the human immunodeficiency virus (HIV) in cell culture infections with a single guide RNA (gRNA) and subsequent viral escape, but complete inactivation of infectious HIV with certain combinations...
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| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7261156/ https://ncbi.nlm.nih.gov/pubmed/32282899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa226 |
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