c-Rel gain in B cells drives germinal center reactions and autoantibody production

Single-nucleotide polymorphisms and locus amplification link the NF-κB transcription factor c-Rel to human autoimmune diseases and B cell lymphomas, respectively. However, the functional consequences of enhanced c-Rel levels remain enigmatic. Here, we overexpressed c-Rel specifically in mouse B cell...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Kober-Hasslacher, Maike, Oh-Strauß, Hyunju, Kumar, Dilip, Soberon, Valeria, Diehl, Carina, Lech, Maciej, Engleitner, Thomas, Katab, Eslam, Fernández-Sáiz, Vanesa, Piontek, Guido, Li, Hongwei, Menze, Björn, Ziegenhain, Christoph, Enard, Wolfgang, Rad, Roland, Böttcher, Jan P., Anders, Hans-Joachim, Rudelius, Martina, Schmidt-Supprian, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260018/
https://ncbi.nlm.nih.gov/pubmed/32191641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124382
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