c-Rel gain in B cells drives germinal center reactions and autoantibody production

Single-nucleotide polymorphisms and locus amplification link the NF-κB transcription factor c-Rel to human autoimmune diseases and B cell lymphomas, respectively. However, the functional consequences of enhanced c-Rel levels remain enigmatic. Here, we overexpressed c-Rel specifically in mouse B cell...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Clin Invest
Hlavní autoři: Kober-Hasslacher, Maike, Oh-Strauß, Hyunju, Kumar, Dilip, Soberon, Valeria, Diehl, Carina, Lech, Maciej, Engleitner, Thomas, Katab, Eslam, Fernández-Sáiz, Vanesa, Piontek, Guido, Li, Hongwei, Menze, Björn, Ziegenhain, Christoph, Enard, Wolfgang, Rad, Roland, Böttcher, Jan P., Anders, Hans-Joachim, Rudelius, Martina, Schmidt-Supprian, Marc
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260018/
https://ncbi.nlm.nih.gov/pubmed/32191641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124382
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky