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Heparin and non-anticoagulant heparin attenuate histone-induced inflammatory responses in whole blood

Cytotoxic and pro-inflammatory histones are present in neutrophil extracellular traps (NETs) and are elevated in blood in several inflammatory conditions, sepsis being a major example. Compounds which can attenuate activities of histones are therefore of interest, with heparin being one such materia...

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Publicat a:PLoS One
Autors principals: Hogwood, John, Pitchford, Simon, Mulloy, Barbara, Page, Clive, Gray, Elaine
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259574/
https://ncbi.nlm.nih.gov/pubmed/32469940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0233644
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