Breakdown of spatial coding and interneuron synchronization in epileptic mice

Temporal lobe epilepsy causes severe cognitive deficits, but the circuit mechanisms remain unknown. Interneuron death and reorganization during epileptogenesis may disrupt the synchrony of hippocampal inhibition. To test this, we simultaneously recorded from the CA1 and dentate gyrus in pilocarpine-...

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Publicado no:Nat Neurosci
Main Authors: Shuman, Tristan, Aharoni, Daniel, Cai, Denise J., Lee, Christopher R., Chavlis, Spyridon, Page-Harley, Lucia, Vetere, Lauren M., Feng, Yu, Yang, Chen Yi, Mollinedo-Gajate, Irene, Chen, Lingxuan, Pennington, Zachary T., Taxidis, Jiannis, Flores, Sergio E., Cheng, Kevin, Javaherian, Milad, Kaba, Christina C., Rao, Naina, La-Vu, Mimi, Pandi, Ioanna, Shtrahman, Matthew, Bakhurin, Konstantin I., Masmanidis, Sotiris C., Khakh, Baljit S., Poirazi, Panayiota, Silva, Alcino J., Golshani, Peyman
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259114/
https://ncbi.nlm.nih.gov/pubmed/31907437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0559-0
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