Olaparib and temozolomide in desmoplastic small round cell tumors: a promising combination in vitro and in vivo

PURPOSE: Desmoplastic small round cell tumors (DSRCTs) are highly malignant and very rare soft tissue sarcomas with a high unmet need for new therapeutic options. Therefore, we examined poly(ADP-ribose) polymerase 1 (PARP1) and Schlafen-11 (SLFN11) expression in DSRCT tumor tissue and the combinatio...

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Udgivet i:J Cancer Res Clin Oncol
Main Authors: van Erp, Anke E. M., van Houdt, Laurens, Hillebrandt-Roeffen, Melissa H. S., van Bree, Niek F. H. N., Flucke, Uta E., Mentzel, Thomas, Shipley, Janet, Desar, Ingrid M. E., Fleuren, Emmy D. G., Versleijen-Jonkers, Yvonne M. H., van der Graaf, Winette T. A.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2020
Fag:
Original Article – Cancer Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7256072/
https://ncbi.nlm.nih.gov/pubmed/32279088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-020-03211-z
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