Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure

BACKGROUND: Despite its cardiotoxicity doxorubicin is widely used for the treatment of paediatric malignancies. Current treatment regimens appear to be suboptimal as treatment strategies vary and do not follow a clear pharmacological rationale. Standardisation of dosing strategies in particular for...

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Detalhes bibliográficos
Publicado no:BMC Pharmacol Toxicol
Main Authors: Siebel, Christian, Würthwein, Gudrun, Lanvers-Kaminsky, Claudia, André, Nicolas, Berthold, Frank, Castelli, Ilaria, Chastagner, Pascal, Doz, François, English, Martin, Escherich, Gabriele, Frühwald, Michael C., Graf, Norbert, Groll, Andreas H., Ruggiero, Antonio, Hempel, Georg, Boos, Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254632/
https://ncbi.nlm.nih.gov/pubmed/32466789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-020-00417-2
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