COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria

The mitochondrial cytochrome c oxidase, the terminal enzyme of the respiratory chain, contains heme and copper centers for electron transfer. The conserved COX2 subunit contains the Cu(A) site, a binuclear copper center. The copper chaperones SCO1, SCO2, and COA6, are required for Cu(A) center forma...

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Udgivet i:J Mol Biol
Main Authors: Pacheu-Grau, David, Wasilewski, Michał, Oeljeklaus, Silke, Gibhardt, Christine Silvia, Aich, Abhishek, Chudenkova, Margarita, Dennerlein, Sven, Deckers, Markus, Bogeski, Ivan, Warscheid, Bettina, Chacinska, Agnieszka, Rehling, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254062/
https://ncbi.nlm.nih.gov/pubmed/32061935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.01.036
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