Downregulation of TET1 Promotes Bladder Cancer Cell Proliferation and Invasion by Reducing DNA Hydroxymethylation of AJAP1

Ten-eleven translocation 1 (TET1) is a member of methylcytosine dioxygenase, which catalyzes 5-methylcytosine (5 mC) to 5-hydroxymethylcytosine (5 hmC) to promote the demethylation process. The dysregulated TET1 protein and 5 hmC level were reported to either suppress or promote carcinogenesis in a...

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Vydáno v:Front Oncol
Hlavní autoři: Yan, Yi-lin, Huang, Zheng-nan, Zhu, Zhen, Cui, Yang-yan, Li, Mei-qian, Huang, Rui-min, Yan, Jun, Shen, Bing
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253684/
https://ncbi.nlm.nih.gov/pubmed/32528872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00667
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