hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma

RNA G-quadruplexes (RG4s) are four-stranded structures known to control mRNA translation of cancer relevant genes. RG4 formation is pervasive in vitro but not in cellulo, indicating the existence of poorly characterized molecular machinery that remodels RG4s and maintains them unfolded. Here, we per...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Herviou, Pauline, Le Bras, Morgane, Dumas, Leïla, Hieblot, Corinne, Gilhodes, Julia, Cioci, Gianluca, Hugnot, Jean-Philippe, Ameadan, Alfred, Guillonneau, François, Dassi, Erik, Cammas, Anne, Millevoi, Stefania
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253433/
https://ncbi.nlm.nih.gov/pubmed/32461552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16168-x
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