TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness

Activator protein (AP)-1 transcription factors are essential elements of the pro-oncogenic functions of transforming growth factor-β (TGFβ)-SMAD signaling. Here we show that in multiple HER2+ and/or EGFR+ breast cancer cell lines these AP-1-dependent tumorigenic properties of TGFβ critically rely on...

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Publicat a:Oncogene
Autors principals: Sundqvist, Anders, Vasilaki, Eleftheria, Voytyuk, Oleksandr, Bai, Yu, Morikawa, Masato, Moustakas, Aristidis, Miyazono, Kohei, Heldin, Carl-Henrik, ten Dijke, Peter, van Dam, Hans
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253358/
https://ncbi.nlm.nih.gov/pubmed/32350443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1299-z
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