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IP(3) mediated global Ca(2+) signals arise through two temporally and spatially distinct modes of Ca(2+) release

The ‘building-block’ model of inositol trisphosphate (IP(3))-mediated Ca(2+) liberation posits that cell-wide cytosolic Ca(2+) signals arise through coordinated activation of localized Ca(2+) puffs generated by stationary clusters of IP(3) receptors (IP(3)Rs). Here, we revise this hypothesis, applyi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lock, Jeffrey T, Parker, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253181/
https://ncbi.nlm.nih.gov/pubmed/32396066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55008
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