The Renin Inhibitor Aliskiren Attenuates High-Glucose Induced Extracellular Matrix Synthesis and Prevents Apoptosis in Cultured Podocytes

BACKGROUND/AIMS: Altered extracellular matrix (ECM) remodeling and podocyte apoptosis are characteristic features of diabetic nephropathy (DN). Aliskiren (ALI) inhibits the renin-catalyzed conversion of angiotensinogen to angiotensin I. This study tested ALI's effect on podocyte ECM accretion a...

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Detalhes bibliográficos
Publicado no:Nephron Exp Nephrol
Main Authors: Phillips, Lynetta M., Wang, Ying, Dai, Tiane, Feldman, David L., LaPage, Janine, Adler, Sharon G.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2011
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7252582/
https://ncbi.nlm.nih.gov/pubmed/21228599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000322242
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