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Determining degradation intermediates and the pathway of 3’ to 5’ degradation of histone mRNA using high-throughput sequencing

The half-life of an mRNA is an important parameter contributing to the steady-state level of the mRNA. Rapid changes in mRNA levels can result from decreasing the half-life of an mRNA. Establishing the detailed pathway of mRNA degradation for a particular class of mRNAs requires the ability to isola...

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Détails bibliographiques
Publié dans:Methods
Auteurs principaux: Holmquist, Christopher E., Marzluff, William F.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7252413/
https://ncbi.nlm.nih.gov/pubmed/30408609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2018.11.001
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