Influence of extracorporeal membrane oxygenation on the pharmacokinetics of ceftolozane/tazobactam: an ex vivo and in vivo study

BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is increasingly used in intensive care units and can modify drug pharmacokinetics and lead to under-exposure associated with treatment failure. Ceftolozane/tazobactam is an antibiotic combination used for complicated infections in critically ill...

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Détails bibliographiques
Publié dans:J Transl Med
Auteurs principaux: Mané, Camille, Delmas, Clément, Porterie, Jean, Jourdan, Géraldine, Verwaerde, Patrick, Marcheix, Bertrand, Concordet, Didier, Georges, Bernard, Ruiz, Stéphanie, Gandia, Peggy
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7251674/
https://ncbi.nlm.nih.gov/pubmed/32460856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02381-1
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