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Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease
Tau is a hallmark pathology of Alzheimer’s disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in humans using an epidemic spreading model (ESM) to simulate tau spread, and compare these sim...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7251068/ https://ncbi.nlm.nih.gov/pubmed/32457389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15701-2 |
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