p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer

The Rho family of GTPases is strictly regulated by a large family of GTPase-activating proteins (GAPs) that stimulate the relatively weak intrinsic GTP-hydrolyzing activity of Rho GTPases. p190A is a potent and widely expressed GAP that acts on RhoA GTPases. p190A is frequently mutated in endometria...

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Detaylı Bibliyografya
Yayımlandı:Signal Transduct Target Ther
Asıl Yazarlar: Wen, Xiaoli, Wan, Jing, He, Qizhi, Wang, Mengfei, Li, Shuangdi, Jiang, Mei, Qian, Zhen, Liu, Binya, Lu, Wen, Wang, Kai, Gao, Kun, Wan, Xiaoping
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7250911/
https://ncbi.nlm.nih.gov/pubmed/32457342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-020-0170-6
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