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Dysregulation of type I interferon responses in COVID-19

Infection with SARS-CoV-2 can lead to excessive production of pro-inflammatory cytokines, but the production of type I interferons, which are key antiviral mediators, is reportedly blunted. Here, we discuss how imbalanced interferon responses may contribute to the pathology of COVID-19.

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Rev Immunol
Prif Awduron: Acharya, Dhiraj, Liu, GuanQun, Gack, Michaela U.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7249038/
https://ncbi.nlm.nih.gov/pubmed/32457522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41577-020-0346-x
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