The Jeff Mouse Mutant Model for Chronic Otitis Media Manifests Gain-of-Function as Well as Loss-of-Function Effects

Chronic otitis media (OM) is the most common cause of hearing loss worldwide, yet the underlying genetics and molecular pathology are poorly understood. The mouse mutant Jeff is a single gene mouse model for OM identified from a deafness screen as part of an ENU mutagenesis program at MRC Harwell. J...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Kubinyecz, Oana, Vikhe, Pratik P., Purnell, Thomas, Brown, Steve D. M., Tateossian, Hilda
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248398/
https://ncbi.nlm.nih.gov/pubmed/32508883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00498
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