Integration of Digital Pathologic and Transcriptomic Analyses Connects Tumor-Infiltrating Lymphocyte Spatial Density With Clinical Response to BRAF Inhibitors

Metastatic melanoma is one of the most immunogenic malignancies due to its high rate of mutations and neoantigen formation. Response to BRAF inhibitors (BRAFi) may be determined by intratumoral immune activation within melanoma metastases. To evaluate whether CD8+ T cell infiltration and distributio...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Ziemys, Arturas, Kim, Michelle, Menzies, Alexander M., Wilmott, James S., Long, Georgina V., Scolyer, Richard A., Kwong, Larry, Holder, Ashley, Boland, Genevieve
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247820/
https://ncbi.nlm.nih.gov/pubmed/32528881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00757
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