An α5 GABAA Receptor Inverse Agonist, α5IA, Attenuates Amyloid Beta-Induced Neuronal Death in Mouse Hippocampal Cultures

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder for which no cognition-restoring therapies exist. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain. Increasing evidence suggests a remodeling of the GABAergic system in AD, which might represen...

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Pubblicato in:Int J Mol Sci
Autori principali: Vinnakota, Chitra, Govindpani, Karan, Tate, Warren Perry, Peppercorn, Katie, Anekal, Praju Vikas, Waldvogel, Henry John, Faull, Richard Lewis Maxwell, Kwakowsky, Andrea
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7247548/
https://ncbi.nlm.nih.gov/pubmed/32384683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21093284
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