Loss of Spry1 reduces growth of BRAF(V600)-mutant cutaneous melanoma and improves response to targeted therapy

Mitogen-activated protein kinase (MAPK) pathway activation is a central step in BRAF(V600)-mutant cutaneous melanoma (CM) pathogenesis. In the last years, Spry1 has been frequently described as an upstream regulator of MAPK signaling pathway. However, its specific role in BRAF(V600)-mutant CM is sti...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Montico, Barbara, Colizzi, Francesca, Giurato, Giorgio, Rizzo, Aurora, Salvati, Annamaria, Baboci, Lorena, Benedetti, Dania, Pivetta, Eliana, Covre, Alessia, Bo, Michele Dal, Weisz, Alessandro, Steffan, Agostino, Maio, Michele, Sigalotti, Luca, Fratta, Elisabetta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244546/
https://ncbi.nlm.nih.gov/pubmed/32444628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2585-y
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