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Surrogate endpoints for overall survival in randomised controlled trials of localised osteosarcoma: A meta-analytic evaluation

Event-free survival (EFS) is considered the most reliable surrogate endpoint for overall survival (OS) in randomised controlled trials (RCTs) of adjuvant therapies for malignant tumours. However, the surrogacy of intermediate endpoints such as EFS for OS in trials of patients with osteosarcoma has n...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Tanaka, Kazuhiro, Kawano, Masanori, Iwasaki, Tatsuya, Matsuda, Shogo, Itonaga, Ichiro, Tsumura, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244479/
https://ncbi.nlm.nih.gov/pubmed/32444660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65591-z
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