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Surrogate endpoints for overall survival in randomised controlled trials of localised osteosarcoma: A meta-analytic evaluation

Event-free survival (EFS) is considered the most reliable surrogate endpoint for overall survival (OS) in randomised controlled trials (RCTs) of adjuvant therapies for malignant tumours. However, the surrogacy of intermediate endpoints such as EFS for OS in trials of patients with osteosarcoma has n...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tanaka, Kazuhiro, Kawano, Masanori, Iwasaki, Tatsuya, Matsuda, Shogo, Itonaga, Ichiro, Tsumura, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244479/
https://ncbi.nlm.nih.gov/pubmed/32444660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65591-z
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