The strategic combination of trastuzumab emtansine with oncolytic rhabdoviruses leads to therapeutic synergy

We have demonstrated that microtubule destabilizing agents (MDAs) can sensitize tumors to oncolytic vesicular stomatitis virus (VSVΔ51) in various preclinical models of cancer. The clinically approved T-DM1 (Kadcyla®) is an antibody-drug conjugate consisting of HER2-targeting trastuzumab linked to t...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Arulanandam, Rozanne, Taha, Zaid, Garcia, Vanessa, Selman, Mohammed, Chen, Andrew, Varette, Oliver, Jirovec, Anna, Sutherland, Keara, Macdonald, Elizabeth, Tzelepis, Fanny, Birdi, Harsimrat, Alluqmani, Nouf, Landry, Anne, Bergeron, Anabel, Vanderhyden, Barbara, Diallo, Jean-Simon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244474/
https://ncbi.nlm.nih.gov/pubmed/32444806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-0972-7
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