Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

Inflammation is an essential part of immunity against pathogens and tumors but can promote disease if not tightly regulated. Self and non-self-nucleic acids can trigger inflammation, through recognition by the cyclic GMP-AMP (cGAMP) synthetase (cGAS) and subsequent activation of the stimulator of in...

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Udgivet i:Sci Adv
Main Authors: Guerra, J., Valadao, A.-L., Vlachakis, D., Polak, K., Vila, I. K., Taffoni, C., Prabakaran, T., Marriott, A. S., Kaczmarek, R., Houel, A., Auzemery, B., Déjardin, S., Boudinot, P., Nawrot, B., Jones, N. J., Paludan, S. R., Kossida, S., Langevin, C., Laguette, N.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244319/
https://ncbi.nlm.nih.gov/pubmed/32494729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax3333
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