In-vivo Imaging of Mitochondrial Depolarization of Myocardium With Positron Emission Tomography and a Proton Gradient Uncoupler

BACKGROUND: We recently reported a method using positron emission tomography (PET) and the tracer (18)F-labeled tetraphenylphosphonium ((18)F-TPP(+)) for mapping the tissue (i.e., cellular plus mitochondrial) membrane potential (ΔΨ(T)) in the myocardium. The purpose of this work is to provide additi...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Alpert, Nathaniel M., Pelletier-Galarneau, Matthieu, Kim, Sally Ji Who, Petibon, Yoann, Sun, Tao, Ramos-Torres, Karla M., Normandin, Marc D., El Fakhri, Georges
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7243673/
https://ncbi.nlm.nih.gov/pubmed/32499721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00491
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