Hyperuricemia Predisposes to the Onset of Diabetes via Promoting Pancreatic β-Cell Death in Uricase-Deficient Male Mice

Clinical studies have shown a link between hyperuricemia (HU) and diabetes, while the exact effect of soluble serum urate on glucose metabolism remains elusive. This study aims to characterize the glucose metabolic phenotypes and investigate the underlying molecular mechanisms using a novel spontane...

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Veröffentlicht in:Diabetes
Hauptverfasser: Lu, Jie, He, Yuwei, Cui, Lingling, Xing, Xiaoming, Liu, Zhen, Li, Xinde, Zhang, Hui, Li, Hailong, Sun, Wenyan, Ji, Aichang, Wang, Yao, Yin, Huiyong, Li, Changgui
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2020
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7243290/
https://ncbi.nlm.nih.gov/pubmed/32312870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0704
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