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Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitylation as a Novel Pharmaceutical Target for Cystic Fibrosis

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene decrease the structural stability and function of the CFTR protein, resulting in cystic fibrosis. Recently, the effect of CFTR-targeting combination therapy has dramatically increased, and it is expected that add-on dru...

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Bibliographic Details
Published in:Pharmaceuticals (Basel)
Main Authors: Fukuda, Ryosuke, Okiyoneda, Tsukasa
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7243099/
https://ncbi.nlm.nih.gov/pubmed/32331485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph13040075
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