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Sildenafil for the Treatment of Alzheimer’s Disease: A Systematic Review
Nitric oxide/cyclic guanosine monophosphate (cGMP) signaling is compromised in Alzheimer’s disease (AD), and phosphodiesterase 5 (PDE5), which degrades cGMP, is upregulated. Sildenafil inhibits PDE5 and increases cGMP levels. Integrating previous findings, we determine that most doses of sildenafil...
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| Publicado no: | J Alzheimers Dis Rep |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
IOS Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7242821/ https://ncbi.nlm.nih.gov/pubmed/32467879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/ADR-200166 |
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