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Reagent-Controlled α‑Selective Dehydrative Glycosylation of 2,6-Dideoxy Sugars: Construction of the Arugomycin Tetrasaccharide

The first synthesis of the tetrasaccharide fragment of the anthracycline natural product Arugomycin is described. A reagent controlled dehydrative glycosylation method involving cyclopropenium activation was utilized to synthesize the α-linkages with complete anomeric selectivity. The synthesis was...

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Pubblicato in:Org Lett
Autori principali: Romeo, Joseph R., McDermott, Luca, Bennett, Clay S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239334/
https://ncbi.nlm.nih.gov/pubmed/32281384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c01153
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