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The cell-permeable mitochondrial calcium uniporter inhibitor Ru265 preserves cortical neuron respiration after lethal oxygen glucose deprivation and reduces hypoxic/ischemic brain injury
The mitochondrial calcium (Ca(2+)) uniporter (MCU) mediates high-capacity mitochondrial Ca(2+) uptake implicated in ischemic/reperfusion cell death. We have recently shown that inducible MCU ablation in Thy1-expressing neurons renders mice resistant to sensorimotor deficits and forebrain neuron loss...
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| Publicado no: | J Cereb Blood Flow Metab |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7238378/ https://ncbi.nlm.nih.gov/pubmed/32126877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X20908523 |
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