Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis

Acute kidney injury (AKI) is a major complication of sepsis. Nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasomes are multiprotein complexes that mediate septic AKI. L-arginine (Arg) is a conditionally essential amino acid in catabolic conditions and a substrate for nitric oxide (...

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Dettagli Bibliografici
Pubblicato in:Mediators Inflamm
Autori principali: Tanuseputero, Sharon Angela, Lin, Ming-Tsan, Yeh, Sung-Ling, Yeh, Chiu-Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2020
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7238342/
https://ncbi.nlm.nih.gov/pubmed/32454788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/3201635
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