The anti-angiogenic tyrosine kinase inhibitor Pazopanib kills cancer cells and disrupts endothelial networks in biomimetic three-dimensional renal tumouroids

Pazopanib is a tyrosine kinase inhibitor used to treat renal cell carcinoma. Few in vitro studies investigate its effects towards cancer cells or endothelial cells in the presence of cancer. We tested the effect of Pazopanib on renal cell carcinoma cells (CAKI-2,786-O) in two-dimensional and three-d...

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Bibliographic Details
Published in:J Tissue Eng
Main Authors: Stamati, Katerina, Redondo, Patricia A, Nyga, Agata, Neves, Joana B, Tran, Maxine GB, Emberton, Mark, Cheema, Umber, Loizidou, Marilena
Format: Artigo
Language:Inglês
Published: SAGE Publications 2020
Subjects:
Technological Advances in 3D Tissue and Organ Models
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7238304/
https://ncbi.nlm.nih.gov/pubmed/32489578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2041731420920597
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