Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization

Background: Capsaicin (CPS) is a highly selective agonist of the transient receptor potential vanilloid type 1 (TRPV1) with a nanomolar affinity. High doses or prolonged exposure to CPS induces TRPV1 defunctionalization and, although this effect is currently used for the treatment of thermal hyperal...

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Bibliografiska uppgifter
I publikationen:Pharmaceutics
Huvudupphovsmän: Puglia, Carmelo, Santonocito, Debora, Bonaccorso, Angela, Musumeci, Teresa, Ruozi, Barbara, Pignatello, Rosario, Carbone, Claudia, Parenti, Carmela, Chiechio, Santina
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7238012/
https://ncbi.nlm.nih.gov/pubmed/32290081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12040339
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