Thanatin Impairs Lipopolysaccharide Transport Complex Assembly by Targeting LptC–LptA Interaction and Decreasing LptA Stability

The outer membrane (OM) of Gram-negative bacteria is a highly selective permeability barrier due to its asymmetric structure with lipopolysaccharide (LPS) in the outer leaflet. In Escherichia coli, LPS is transported to the cell surface by the LPS transport (Lpt) system composed of seven essential p...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Moura, Elisabete C. C. M., Baeta, Tiago, Romanelli, Alessandra, Laguri, Cedric, Martorana, Alessandra M., Erba, Emanuela, Simorre, Jean-Pierre, Sperandeo, Paola, Polissi, Alessandra
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7237710/
https://ncbi.nlm.nih.gov/pubmed/32477309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.00909
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