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Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
Progressive telomere shortening during lifespan is associated with restriction of cell proliferation, genome instability and aging. Apoptosis and senescence are the two major outcomes upon irreversible cellular damage. Here, we show a transition of these two cell fates during aging of telomerase def...
Gorde:
| Argitaratua izan da: | eLife |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
eLife Sciences Publications, Ltd
2020
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7237213/ https://ncbi.nlm.nih.gov/pubmed/32427102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54935 |
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