Regulation of the Ysh1 endonuclease of the mRNA cleavage/polyadenylation complex by ubiquitin-mediated degradation

Mutation of the essential yeast protein Ipa1 has previously been demonstrated to cause defects in pre-mRNA 3ʹ end processing and growth, but the mechanism underlying these defects was not clear. In this study, we show that the ipa1-1 mutation causes a striking depletion of Ysh1, the evolutionarily c...

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Библиографические подробности
Опубликовано в: :RNA Biol
Главные авторы: Lee, Susan D., Liu, Hui-Yun, Graber, Joel H., Heller-Trulli, Daniel, Kaczmarek Michaels, Katarzyna, Cerezo, Juan Francisco, Moore, Claire L.
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2020
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7237158/
https://ncbi.nlm.nih.gov/pubmed/32009536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2020.1724717
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