sEH Inhibitor Tppu Ameliorates Cecal Ligation and Puncture-Induced Sepsis by Regulating Macrophage Functions

BACKGROUND: Sepsis is a life-threatening organ dysfunction initiated by a dysregulated response to infection, with imbalanced inflammation and immune homeostasis. Macrophages play a pivotal role in sepsis. N-[1-(1-oxopropyl)-4-piperidinyl]-N’-[4-(trifluoromethoxy)phenyl)-urea (TPPU) is an inhibitor...

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Bibliografische gegevens
Gepubliceerd in:Shock
Hoofdauteurs: Chen, Zhihui, Tang, Ying, Yu, Jing, Dong, Ruolan, Yang, Yan, Fu, Menglu, Luo, Jinlan, Hu, Shuiqing, Wang, Dao Wen, Tu, Ling, Xu, Xizhen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Lippincott Williams & Wilkins 2020
Onderwerpen:
Basic Science Aspects
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7237073/
https://ncbi.nlm.nih.gov/pubmed/31318834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000001408
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